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Ebglyss
Brand Name
EbglyssCommon Name
lebrikizumabIn this drug factsheet:
- How does this medication work? What will it do for me?
- How should I use this medication?
- What form(s) does this medication come in?
- Who should NOT take this medication?
- What side effects are possible with this medication?
- Are there any other precautions or warnings for this medication?
- What other drugs could interact with this medication?
DIN (Drug Identification Number)
02549123 | Ebglyss 250 mg Prefilled Pen for Injection |
How does this medication work? What will it do for me?
Lebrikizumab belongs to the class of medications called immunomodulators, more specifically interleukin inhibitors. It is used by adults and children 12 years of age and older who weigh 40 kg or more, to treat moderate-to-severe atopic dermatitis (sometimes referred to as eczema) when topical medications are not controlling the symptoms or are not appropriate. It may be used alone or with corticosteroid creams and ointments, or topical tacrolimus ointment.
Lebrikizumab blocks the action of interleukin, a protein in the body which causes inflammation. This reduces symptoms of atopic dermatitis, such as redness, itching, and inflamed skin.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
How should I use this medication?
The starting dose of lebrikizumab is 500 mg (2 × 250 mg injections) injected subcutaneously (under the skin) once, and then again 2 weeks later. After the first 2 doses, 250 mg is injected subcutaneously every 2 weeks for 7 doses. This is a total of 16 weeks of treatment. After 16 weeks of injections, your doctor will decrease the dose to 250 mg injected every 4 weeks.
If you are injecting this medication yourself, your doctor will show you how to use this medication properly. If you are not sure how to use it or have questions about how to use it, contact your doctor. Before using this medication, thoroughly read the patient information provided and ask your doctor any questions you might have. If a caregiver will be giving you the injections, your doctor should instruct them on how to give the injection.
Use a different injection site for each dose. You should avoid injecting this medication into an area of skin that is sore, red, infected, bruised, or otherwise damaged. If you are having difficulty giving yourself injections, talk to your health care provider.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and start a new 2-week schedule from the day you take the missed dose. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Lebrikizumab should be clear and colourless. Do not use lebrikizumab if you notice particles or anything unusual in the appearance of the solution. Do not shake this medication.
Store this medication in the refrigerator. Keep it in its outer carton to protect it from light. Remove it from the refrigerator and allow it to sit at room temperature for 45 minutes before injecting. If necessary, this medication may be kept at room temperature for up to 7 days. Keep this medication out of the reach and sight of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
What form(s) does this medication come in?
Each mL of clear, colourless-to-slightly-yellow, particle-free and preservative-free sterile solution, contains 125 mg of lebrikizumab. Nonmedicinal ingredients: glacial acetic acid, histidine, polysorbate 20, sucrose, and water for injection.
Who should NOT take this medication?
Do not take this medication if you are allergic to lebrikizumab or any ingredients of the medication.
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- dry, itchy, red or swollen eyes
- red, swollen or itchy eyelids
- redness, itching, or swelling at the injection site
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- symptoms of shingles (e.g., painful, itchy, reddish, fluid-filled blisters on one side of the body)
Stop taking the medication and seek immediate medical attention if any of the following occur:
- signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Allergic reactions: Some people may develop an allergic reaction to this medication. Signs of an allergic reaction include a severe rash, hives, swollen face or throat, or difficulty breathing. If these occur, contact your doctor immediately.
Eye problems: Inflammation of the cornea of the eye and the white part of the eye have been reported by people using lebrikizumab. If you experience symptoms such as red eyes, moderate-to-severe eye pain, a feeling of grittiness in the eye, or increased sensitivity to light, contact your doctor as soon as possible.
Parasite infections: This medication may weaken your resistance to parasite infections. If you already have a parasite infection it should be treated before starting this medication. If you are living in or travelling to a region where parasite infections are frequent, discuss with your doctor any special precautions that may be needed.
Vaccines: Live vaccines (e.g., yellow fever, BCG, cholera, typhoid, varicella) should not be given when you are taking lebrikizumab. Talk to your doctor about whether there are any vaccines you should have before starting this medication.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if lebrikizumab passes into breast milk. If you are breast-feeding and taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children under 12 years of age or weighing less than 40 kg.
What other drugs could interact with this medication?
For a full list of interactions, use the Drug Interaction Checker available on the Drugs.com website.
If you are taking other medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 – 2025. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Ebglyss